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KMID : 0869620160330040367
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Journal of Korean Society of Hospital Pharmacists
2016 Volume.33 No. 4 p.367 ~ p.379
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Potential Role of Omega n-3 Polyunsaturated Fatty Acids and Its Use in Rheumatoid Arthritis
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Jo Eui-Sang
Choi Kyung-Hee
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Abstract
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Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown cause. It is characterized by polyarthritis. Currently, treatments for RA include the use of non-steroidal antiinflammatory drugs (NSAIDs), steroid, disease-modifying antirheumatic drugs (DMARDs), corticosteroid, and so on. New treatment options for RA have been actively developed. In this study, we determined pharmacological advantages of using omega n-3 polyunsaturated fatty acids (PUFAs) as adjunctive therapy in RA based on articles demonstrating the role of omega n-3 in the prevention and treatment of RA.
Omega n-3 PUFAs can partially suppress a number of inflammatory reactions such as leukocyte chemotaxis and adhesion molecule expression. Mechanisms fundamental to the anti-inflammatory actions of omega n-3 PUFAs involve changing the compositions of cell membrane's phospholipid fatty acids. Omega n-3 PUFAs with inflammation control action may also result in the reduction of pain in rheumatoid arthritis. The benefit of n-3 PUFAs in RA has also been suggested in some clinical studies. In conclusion, omega n-3 PUFAs might be useful as an adjuvant therapy for the treatment of RA.
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KEYWORD
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Rheumatoid arthritis, Omega n-3 polyunsaturated fatty acids, Anti-inflammation effect, Pain control
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